| 1. Round | 18/09/2020 | Inter Playa | - | Cafessa Jalisco | 2:1 | ||||
| 2. Round | 27/09/2020 | Cafessa Jalisco | - | Cafetaleros de Chiapas | 3:3 | ||||
| 4. Round | 10/10/2020 | Cafessa Jalisco | - | Azores de Hidalgo | 0:0 | ||||
| 6. Round | 25/10/2020 | Cafessa Jalisco | - | Club Irapuato | 4:3 | ||||
| 7. Round | 02/11/2020 | Club de Ciervos | - | Cafessa Jalisco | 0:5 |  |
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| 8. Round | 08/11/2020 | Cafessa Jalisco | - | Cañoneros Marina | 1:0 | |
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| 9. Round | 15/11/2020 | Cruz Azul Hidalgo | - | Cafessa Jalisco | 0:1 | ||||
| 10. Round | 22/11/2020 | Cafessa Jalisco | - | CD Cuautla | 2:2 | ||||
| 11. Round | 29/11/2020 | Deportivo Dongu | - | Cafessa Jalisco | 0:1 | ||||
| 13. Round | 12/12/2020 | Pioneros de Cancún | - | Cafessa Jalisco | 0:3 | ||||
| 3. Round | 16/12/2020 | Zitácuaro | - | Cafessa Jalisco | 1:3 | |
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| 14. Round | 17/01/2021 | Cafessa Jalisco | - | Inter Playa | 0:2 | ||||
| 15. Round | 23/01/2021 | Cafetaleros de Chiapas | - | Cafessa Jalisco | 0:0 | ||||
| 16. Round | 02/02/2021 | Cafessa Jalisco | - | Zitácuaro | 2:0 | ||||
| 17. Round | 07/02/2021 | Azores de Hidalgo | - | Cafessa Jalisco | 2:0 | |
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| 19. Round | 19/02/2021 | Club Irapuato | - | Cafessa Jalisco | 0:0 |
Mexico