| 8. Round | 12/09/2021 | FCSB | - | Dinamo Bucureşti | 6:0 | ||||
| 10. Round | 25/09/2021 | FCSB | - | Academica Clinceni | 3:2 |  |
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| 11. Round | 01/10/2021 | Chindia Târgoviște | - | FCSB | 0:1 | ||||
| 14. Round | 31/10/2021 | FCSB | - | Argeș Pitești | 2:1 | ||||
| 13. Round | 04/11/2021 | Farul Constanța | - | FCSB | 0:1 | ||||
| 15. Round | 07/11/2021 | FC Voluntari | - | FCSB | 0:0 | |
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| 16. Round | 21/11/2021 | FCSB | - | FC Botoşani | 3:1 | |
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| 17. Round | 28/11/2021 | CS Universitatea Craiova | - | FCSB | 2:3 |  |
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| 18. Round | 05/12/2021 | FCSB | - | UTA Arad | 2:1 | ||||
| 19. Round | 11/12/2021 | Gaz Metan Mediaş | - | FCSB | 0:1 | ||||
| 20. Round | 15/12/2021 | FCSB | - | Rapid Bucureşti | 3:1 | ||||
| 21. Round | 19/12/2021 | Sepsi OSK | - | FCSB | 0:0 | ||||
| 22. Round | 23/01/2022 | FCSB | - | CFR Cluj | 3:3 | |
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| 24. Round | 06/02/2022 | FCSB | - | FC Universitatea Craiova | 2:2 | |
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| 30. Round | 06/03/2022 | FCSB | - | FC Voluntari | 1:0 |
Romania