| Group D | 16/09/2021 | Olympiakos Piraeus | - | Royal Antwerp FC | 2:1 |  |
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| Group D | 30/09/2021 | Fenerbahçe | - | Olympiakos Piraeus | 0:3 | ||||
| Group D | 21/10/2021 | Eintracht Frankfurt | - | Olympiakos Piraeus | 3:1 | ||||
| Group D | 04/11/2021 | Olympiakos Piraeus | - | Eintracht Frankfurt | 1:2 | ||||
| Group D | 25/11/2021 | Olympiakos Piraeus | - | Fenerbahçe | 1:0 | ||||
| Group D | 09/12/2021 | Royal Antwerp FC | - | Olympiakos Piraeus | 1:0 | ||||
| Play-offs | 17/02/2022 | Atalanta | - | Olympiakos Piraeus | 2:1 | ||||
| Play-offs | 24/02/2022 | Olympiakos Piraeus | - | Atalanta | 0:3 |
Guinea