| 4. Round | 19/11/2021 | Al Ahly SC | - | Al Mokawloon | 1:0 |  |
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| 5. Round | 23/11/2021 | Al Mokawloon | - | Ismaily | 1:1 | ||||
| 8. Round | 24/12/2021 | Ceramica Cleopatra | - | Al Mokawloon | 2:2 | ||||
| 9. Round | 15/02/2022 | Ghazl Al Mehalla | - | Al Mokawloon | 1:1 | ||||
| 12. Round | 04/03/2022 | Al Mokawloon | - | Pyramids FC | 0:2 | ||||
| 13. Round | 16/03/2022 | El Gouna | - | Al Mokawloon | 1:2 | |
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| 14. Round | 14/04/2022 | Al Mokawloon | - | Misr lel-Maqasah SC | 1:1 | ||||
| 17. Round | 01/05/2022 | Al Masry Club | - | Al Mokawloon | 0:2 | ||||
| 18. Round | 09/05/2022 | El Sharkia Lel Dokhan | - | Al Mokawloon | 1:1 | ||||
| 22. Round | 17/06/2022 | Ismaily | - | Al Mokawloon | 0:0 | ||||
| 28. Round | 02/08/2022 | Al Mokawloon | - | Future FC | 0:1 | |
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| 30. Round | 10/08/2022 | Al Mokawloon | - | El Gouna | 0:0 |
Egypt