| 10. Round | 21/02/2022 | Al Mokawloon | - | Smouha Sporting Club | 0:0 | ||||
| 11. Round | 25/02/2022 | Future FC | - | Al Mokawloon | 1:0 |  |
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| 12. Round | 04/03/2022 | Al Mokawloon | - | Pyramids FC | 0:2 | ||||
| 13. Round | 16/03/2022 | El Gouna | - | Al Mokawloon | 1:2 | |
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| 14. Round | 14/04/2022 | Al Mokawloon | - | Misr lel-Maqasah SC | 1:1 | |
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| 16. Round | 26/04/2022 | Al Mokawloon | - | Ittihad El Iskandary | 1:1 |
Egypt