| 4. Round | 13/09/2021 | Gaziantep FK | - | Antalyaspor | 2:0 |  |
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| 5. Round | 18/09/2021 | Sivasspor | - | Gaziantep FK | 1:1 | ||||
| 6. Round | 22/09/2021 | Gaziantep FK | - | İstanbul Başakşehir | 1:0 | ||||
| 7. Round | 25/09/2021 | Adana Demirspor | - | Gaziantep FK | 4:0 | ||||
| 8. Round | 03/10/2021 | Gaziantep FK | - | Altay Izmir | 4:1 | ||||
| 9. Round | 18/10/2021 | Hatayspor | - | Gaziantep FK | 2:1 | ||||
| 10. Round | 23/10/2021 | Gaziantep FK | - | Giresunspor | 1:1 | ||||
| 17. Round | 19/12/2021 | Kayserispor | - | Gaziantep FK | 0:0 | ||||
| 20. Round | 08/01/2022 | Gaziantep FK | - | Fatih Karagümrük | 3:1 | ||||
| 23. Round | 23/01/2022 | Antalyaspor | - | Gaziantep FK | 0:0 | ||||
| 26. Round | 20/02/2022 | Gaziantep FK | - | Adana Demirspor | 0:3 | ||||
| 28. Round | 07/03/2022 | Gaziantep FK | - | Hatayspor | 2:2 | ||||
| 29. Round | 14/03/2022 | Giresunspor | - | Gaziantep FK | 2:1 | ||||
| 30. Round | 20/03/2022 | Gaziantep FK | - | Galatasaray | 3:1 | ||||
| 31. Round | 03/04/2022 | Kasımpaşa SK | - | Gaziantep FK | 2:1 | |
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| 38. Round | 20/05/2022 | Gaziantep FK | - | Çaykur Rizespor | 2:0 |
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