| 1. Round | 27/10/2021 | Pyramids FC | - | Misr lel-Maqasah SC | 2:1 | ||||
| 2. Round | 31/10/2021 | Pharco FC | - | Pyramids FC | 1:2 | ||||
| 4. Round | 19/11/2021 | Al Masry Club | - | Pyramids FC | 2:2 | ||||
| 5. Round | 22/11/2021 | Pyramids FC | - | El Sharkia Lel Dokhan | 3:0 | ||||
| 7. Round | 21/12/2021 | Pyramids FC | - | Tala'ea El Gaish SC | 3:0 | ||||
| 6. Round | 25/12/2021 | ENPPI | - | Pyramids FC | 1:1 | ||||
| 13. Round | 09/04/2022 | Pyramids FC | - | Ghazl Al Mehalla | 1:0 | ||||
| 22. Round | 22/06/2022 | El Sharkia Lel Dokhan | - | Pyramids FC | 0:3 | ||||
| 24. Round | 12/07/2022 | Tala'ea El Gaish SC | - | Pyramids FC | 2:2 |  |
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| 25. Round | 16/07/2022 | Pyramids FC | - | Al Ahly SC | 2:0 | |
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| 26. Round | 24/07/2022 | Ismaily | - | Pyramids FC | 0:4 | ||||
| 27. Round | 27/07/2022 | Pyramids FC | - | National Bank SC | 1:0 | ||||
| 28. Round | 01/08/2022 | Zamalek | - | Pyramids FC | 3:0 | ||||
| 29. Round | 06/08/2022 | Pyramids FC | - | Al Mokawloon | 1:0 | ||||
| 30. Round | 09/08/2022 | Ghazl Al Mehalla | - | Pyramids FC | 0:2 | ||||
| 31. Round | 19/08/2022 | Pyramids FC | - | Smouha Sporting Club | 5:1 | ||||
| 33. Round | 26/08/2022 | Ceramica Cleopatra | - | Pyramids FC | 0:2 | ||||
| 34. Round | 30/08/2022 | Pyramids FC | - | El Gouna | 1:3 |
Egypt