| Round of 16 | 01/12/2021 | Panathinaikos | - | Volos NFC | 2:1 | ||||
| Round of 16 | 23/12/2021 | Volos NFC | - | Panathinaikos | 0:0 | ||||
| Quarter-finals | 19/01/2022 | Panathinaikos | - | Anagennisi Karditsa | 4:0 |  |
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| Quarter-finals | 09/02/2022 | Anagennisi Karditsa | - | Panathinaikos | 0:1 | ||||
| Semi-finals | 20/04/2022 | Panathinaikos | - | Lamia | 1:0 | ||||
| Semi-finals | 27/04/2022 | Lamia | - | Panathinaikos | 0:2 | ||||
| Final | 21/05/2022 | Panathinaikos | - | PAOK Saloniki | 1:0 | |
Spain