| 1. Round | 13/03/2022 | Panathinaikos | - | AEK Athen | 1:1 |  |
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| 2. Round | 20/03/2022 | Aris Saloniki | - | Panathinaikos | 0:0 |  |
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| 3. Round | 03/04/2022 | Panathinaikos | - | PAOK Saloniki | 2:1 | |
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| 4. Round | 10/04/2022 | PAS Giannina | - | Panathinaikos | 0:0 | |
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| 5. Round | 17/04/2022 | Panathinaikos | - | Olympiakos Piraeus | 1:0 | |
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| 6. Round | 01/05/2022 | Panathinaikos | - | Aris Saloniki | 1:0 | ||||
| 7. Round | 08/05/2022 | AEK Athen | - | Panathinaikos | 0:0 | |
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| 8. Round | 11/05/2022 | Olympiakos Piraeus | - | Panathinaikos | 1:2 | ||||
| 9. Round | 14/05/2022 | Panathinaikos | - | PAS Giannina | 4:0 |
Spain