| 1. Round | 21/08/2022 | Panathinaikos | - | Ionikos Nikea | 1:0 |  |
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| 2. Round | 28/08/2022 | OFI Heraklion | - | Panathinaikos | 0:2 | ||||
| 3. Round | 03/09/2022 | Panathinaikos | - | Levadiakos | 1:0 | ||||
| 4. Round | 11/09/2022 | Panathinaikos | - | AEK Athen | 2:1 | |
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| 5. Round | 17/09/2022 | Panathinaikos | - | PAS Giannina | 3:0 | |
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| 6. Round | 02/10/2022 | PAOK Saloniki | - | Panathinaikos | 1:2 | |
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| 7. Round | 09/10/2022 | Panathinaikos | - | Asteras Tripolis | 1:0 | |
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| 8. Round | 16/10/2022 | Lamia | - | Panathinaikos | 0:2 | ||||
| 9. Round | 23/10/2022 | Panathinaikos | - | Aris Saloniki | 1:0 |
Spain