| 2. Round | 23/07/2021 | Defensa y Justicia II | - | Godoy Cruz II | 2:1 | ||||
| 3. Round | 27/07/2021 | Godoy Cruz II | - | Atlético Tucumán II | 2:2 | ||||
| 4. Round | 30/07/2021 | Colón de Santa Fe II | - | Godoy Cruz II | 0:0 | ||||
| 5. Round | 06/08/2021 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 6. Round | 13/08/2021 | Lanús II | - | Godoy Cruz II | 5:1 | ||||
| 7. Round | 20/08/2021 | Godoy Cruz II | - | Huracán II | 2:1 |  |
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| 14. Round | 01/10/2021 | Godoy Cruz II | - | Newell's Old Boys II | 1:1 |
Argentina