| 10. Round | 08/05/2021 | FK Kairat | - | Shakter Karaganda | 1:1 | ||||
| 11. Round | 14/05/2021 | Shakter Karaganda | - | FK Turan | 0:1 | ||||
| 12. Round | 19/05/2021 | Kaspiy Aktau | - | Shakter Karaganda | 3:0 | ||||
| 13. Round | 24/05/2021 | Shakter Karaganda | - | Tobyl Kostanay | 0:3 | ||||
| 14. Round | 29/05/2021 | FK Ordabasy | - | Shakter Karaganda | 0:0 | ||||
| 15. Round | 12/06/2021 | Shakter Karaganda | - | FK Kyzylzhar | 0:1 | ||||
| 16. Round | 18/06/2021 | Shakter Karaganda | - | FK Taraz | 1:0 |  |
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| 17. Round | 22/06/2021 | FK Akzhayik | - | Shakter Karaganda | 1:1 | ||||
| 18. Round | 27/06/2021 | Shakter Karaganda | - | FK Aktobe | 1:0 | ||||
| 19. Round | 02/07/2021 | FK Astana | - | Shakter Karaganda | 4:3 | ||||
| 20. Round | 12/09/2021 | Shakter Karaganda | - | Zhetysu Taldykorgan | 3:1 | ||||
| 21. Round | 19/09/2021 | Kaysar Kyzylorda | - | Shakter Karaganda | 1:2 | ||||
| 22. Round | 26/09/2021 | Shakter Karaganda | - | FK Kairat | 1:1 | ||||
| 26. Round | 30/10/2021 | Shakter Karaganda | - | FK Atyrau | 3:1 |
Russia