| 1. Round | 07/08/2021 | Oldham Athletic | - | Newport County | 0:1 | ||||
| 4. Round | 21/08/2021 | Oldham Athletic | - | Colchester United | 1:2 |  |
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| 5. Round | 28/08/2021 | Sutton United | - | Oldham Athletic | 1:2 | ||||
| 6. Round | 04/09/2021 | Oldham Athletic | - | Barrow AFC | 0:3 | ||||
| 8. Round | 18/09/2021 | Oldham Athletic | - | Hartlepool United | 0:0 | ||||
| 13. Round | 19/10/2021 | Oldham Athletic | - | Walsall FC | 1:3 |
Ireland