| 5. Round | 26/08/2021 | Barranquilla FC | - | Valledupar FC | 2:1 | ||||
| 6. Round | 30/08/2021 | Valledupar FC | - | Bogotá FC | 0:2 | ||||
| 10. Round | 28/09/2021 | Boyacá Chicó | - | Valledupar FC | 2:0 | ||||
| 11. Round | 03/10/2021 | Valledupar FC | - | Fortaleza FC | 1:1 | ||||
| 13. Round | 19/10/2021 | Valledupar FC | - | Cortuluá | 1:2 | ||||
| 14. Round | 24/10/2021 | Unión Magdalena | - | Valledupar FC | 3:1 | ||||
| 15. Round | 30/10/2021 | Valledupar FC | - | Boca Juniors de Cali | 2:1 |
Colombia