| 1. Round | 23/01/2022 | Valledupar FC | - | Real Santander | 1:0 | ||||
| 2. Round | 29/01/2022 | Atlético FC | - | Valledupar FC | 0:0 | ||||
| 3. Round | 06/02/2022 | Valledupar FC | - | Leones FC | 0:1 | ||||
| 8. Round | 10/03/2022 | Boyacá Chicó | - | Valledupar FC | 2:2 | ||||
| 9. Round | 20/03/2022 | Valledupar FC | - | Boca Juniors de Cali | 2:1 |  |
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| 11. Round | 03/04/2022 | Tigres FC | - | Valledupar FC | 3:2 | ||||
| 12. Round | 10/04/2022 | Valledupar FC | - | Fortaleza FC | 1:1 | ||||
| 13. Round | 16/04/2022 | Barranquilla FC | - | Valledupar FC | 1:1 |
Colombia