| 1. Round | 18/07/2021 | Alianza Lima | - | Ayacucho FC | 4:1 |  |
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| 2. Round | 24/07/2021 | Alianza Universidad | - | Alianza Lima | 0:0 | ||||
| 3. Round | 01/08/2021 | Sport Boys | - | Alianza Lima | 0:0 | ||||
| 4. Round | 05/08/2021 | Alianza Lima | - | Academia Cantolao | 2:1 | ||||
| 5. Round | 08/08/2021 | Universidad San Martín | - | Alianza Lima | 0:2 | ||||
| 6. Round | 14/08/2021 | Alianza Lima | - | Deportivo Municipal | 1:0 | ||||
| 7. Round | 19/08/2021 | Universitario de Deportes | - | Alianza Lima | 1:2 |  |
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| 8. Round | 23/08/2021 | Alianza Lima | - | Sport Huancayo | 1:1 | ||||
| 9. Round | 29/08/2021 | Universidad Cesar Vallejo | - | Alianza Lima | 0:1 | |
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| 10. Round | 12/09/2021 | Alianza Lima | - | Deportivo Binacional | 3:2 | ||||
| 11. Round | 17/09/2021 | Cusco FC | - | Alianza Lima | 0:2 | ||||
| 12. Round | 22/09/2021 | Alianza Lima | - | FBC Melgar | 1:0 | ||||
| 14. Round | 02/10/2021 | Alianza Lima | - | Universidad Técnica | 2:0 | ||||
| 15. Round | 16/10/2021 | Mannucci | - | Alianza Lima | 0:1 | ||||
| 16. Round | 24/10/2021 | Alianza Lima | - | Sporting Cristal | 1:3 | ||||
| 17. Round | 29/10/2021 | Cienciano | - | Alianza Lima | 1:1 |
Peru