| 1. Round | 02/04/2022 | Deportivo Coopsol | - | Los Chankas | 2:0 | ||||
| 2. Round | 10/04/2022 | Santos FC | - | Deportivo Coopsol | 2:2 | ||||
| 4. Round | 23/04/2022 | Deportivo Coopsol | - | Unión Huaral | 0:1 | ||||
| 5. Round | 01/05/2022 | Juan Aurich | - | Deportivo Coopsol | 1:2 | ||||
| 6. Round | 07/05/2022 | Deportivo Coopsol | - | Alianza Universidad | 1:1 | ||||
| 11. Round | 12/06/2022 | Chavelines Juniors | - | Deportivo Coopsol | 0:0 | ||||
| 12. Round | 18/06/2022 | Deportivo Coopsol | - | Pirata | 1:1 |  |
Ecuador