| 1. Round | 13/01/2021 | Jicaral | - | AD San Carlos | 1:1 | ||||
| 2. Round | 18/01/2021 | AD San Carlos | - | CS Herediano | 2:1 | ||||
| 5. Round | 30/01/2021 | AD San Carlos | - | Sporting FC | 0:0 | ||||
| 6. Round | 04/02/2021 | AD San Carlos | - | CS Cartaginés | 1:1 | ||||
| 8. Round | 15/02/2021 | AD San Carlos | - | Municipal Grecia | 1:4 | ||||
| 15. Round | 31/03/2021 | AD San Carlos | - | LD Alajuelense | 0:1 | ||||
| 16. Round | 05/04/2021 | Sporting FC | - | AD San Carlos | 2:0 | ||||
| 21. Round | 01/05/2021 | Limón FC | - | AD San Carlos | 0:3 |
Mexico