1. Round | 16/01/2022 | Sololá FC | - | Cobán Imperial | 0:0 | ||||
2. Round | 22/01/2022 | Cobán Imperial | - | Comunicaciones | 2:0 | ||||
4. Round | 02/02/2022 | Cobán Imperial | - | Xelaju MC | 3:1 | ||||
5. Round | 05/02/2022 | Nueva Concepción | - | Cobán Imperial | 1:2 | ||||
6. Round | 10/02/2022 | Antigua GFC | - | Cobán Imperial | 0:1 | ||||
7. Round | 12/02/2022 | Cobán Imperial | - | Iztapa | 2:0 | ||||
8. Round | 19/02/2022 | CSD Municipal | - | Cobán Imperial | 3:2 | ||||
9. Round | 27/02/2022 | Cobán Imperial | - | Achuapa | 0:1 | ||||
11. Round | 06/03/2022 | Cobán Imperial | - | Deportivo Guastatoya | 0:0 | ||||
12. Round | 12/03/2022 | Cobán Imperial | - | Sololá FC | 2:1 | ||||
13. Round | 20/03/2022 | Comunicaciones | - | Cobán Imperial | 1:4 | ||||
15. Round | 03/04/2022 | Xelaju MC | - | Cobán Imperial | 2:2 | ||||
16. Round | 09/04/2022 | Cobán Imperial | - | Nueva Concepción | 5:1 | ||||
19. Round | 13/04/2022 | Cobán Imperial | - | CSD Municipal | 1:1 | ||||
17. Round | 16/04/2022 | Cobán Imperial | - | Antigua GFC | 0:0 | ||||
18. Round | 20/04/2022 | Iztapa | - | Cobán Imperial | 3:0 | ||||
21. Round | 04/05/2022 | Cobán Imperial | - | Santa Lucía | 1:0 |