| 1. Round | 01/08/2021 | AD Chalatenango | - | Platense Zacatecoluca | 2:2 | ||||
| 2. Round | 07/08/2021 | Atlético Marte | - | AD Chalatenango | 0:2 |  |
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| 3. Round | 11/08/2021 | AD Chalatenango | - | Alianza | 2:1 | ||||
| 5. Round | 21/08/2021 | AD Chalatenango | - | Luis Ángel Firpo | 0:2 | ||||
| 6. Round | 26/08/2021 | CD Águila | - | AD Chalatenango | 2:1 | ||||
| 7. Round | 29/08/2021 | AD Chalatenango | - | Once Municipal | 1:2 | ||||
| 16. Round | 31/10/2021 | Luis Ángel Firpo | - | AD Chalatenango | 4:2 | |
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| 18. Round | 07/11/2021 | Once Municipal | - | AD Chalatenango | 1:2 | ||||
| 19. Round | 14/11/2021 | AD Chalatenango | - | Jocoro FC | 2:0 | ||||
| 20. Round | 17/11/2021 | FAS | - | AD Chalatenango | 1:1 | ||||
| 21. Round | 21/11/2021 | Municipal Limeño | - | AD Chalatenango | 0:3 | ||||
| 22. Round | 27/11/2021 | AD Chalatenango | - | Isidro Metapán | 1:0 |
El Salvador