| 2. Round | 31/07/2021 | BSC Young Boys | - | Grasshopper Club Zürich | 0:0 | ||||
| 3. Round | 07/08/2021 | Grasshopper Club Zürich | - | FC Lausanne-Sport | 3:1 | ||||
| 4. Round | 21/08/2021 | FC Zürich | - | Grasshopper Club Zürich | 2:1 | ||||
| 5. Round | 29/08/2021 | Grasshopper Club Zürich | - | Servette FC | 1:1 | ||||
| 6. Round | 11/09/2021 | FC Luzern | - | Grasshopper Club Zürich | 1:1 | ||||
| 13. Round | 06/11/2021 | Grasshopper Club Zürich | - | BSC Young Boys | 1:1 | ||||
| 18. Round | 19/12/2021 | FC Basel 1893 | - | Grasshopper Club Zürich | 2:2 |
Serbia