| 1. Round | 12/03/2021 | FK Isloch Minsk | - | FK Slaviya Mozyr | 1:0 | ||||
| 2. Round | 19/03/2021 | FK Isloch Minsk | - | FK Smorgon | 2:0 |  |
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| 4. Round | 10/04/2021 | FK Isloch Minsk | - | Rukh Brest | 0:1 | ||||
| 5. Round | 16/04/2021 | Sputnik Rechytsa | - | FK Isloch Minsk | 1:5 | |
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| 6. Round | 25/04/2021 | FK Isloch Minsk | - | BATE Borisov | 1:4 |  |
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| 8. Round | 09/05/2021 | FK Isloch Minsk | - | Dinamo Minsk | 1:3 | |
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| 11. Round | 30/05/2021 | FK Slutsk | - | FK Isloch Minsk | 2:1 | ||||
| 12. Round | 13/06/2021 | FK Isloch Minsk | - | Dinamo Brest | 1:1 | ||||
| 13. Round | 19/06/2021 | FK Gomel | - | FK Isloch Minsk | 2:0 | ||||
| 22. Round | 11/09/2021 | FK Isloch Minsk | - | Neman Grodno | 2:0 | ||||
| 23. Round | 19/09/2021 | Dinamo Minsk | - | FK Isloch Minsk | 2:1 | ||||
| 26. Round | 16/10/2021 | FK Isloch Minsk | - | FK Slutsk | 2:0 | ||||
| 27. Round | 23/10/2021 | Dinamo Brest | - | FK Isloch Minsk | 1:0 | ||||
| 29. Round | 20/11/2021 | FK Minsk | - | FK Isloch Minsk | 1:0 | ||||
| 30. Round | 28/11/2021 | FK Isloch Minsk | - | Energetik-BGU Minsk | 0:4 |
Belarus