| 1. Round | 24/07/2022 | RSC Anderlecht | - | KV Oostende | 2:0 | ||||
| 2. Round | 30/07/2022 | KV Oostende | - | KV Mechelen | 2:1 |  |
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| 5. Round | 20/08/2022 | KV Oostende | - | Sint-Truidense VV | 0:1 | ||||
| 6. Round | 27/08/2022 | Oud-Heverlee Leuven | - | KV Oostende | 2:1 | ||||
| 7. Round | 03/09/2022 | Standard Liège | - | KV Oostende | 1:0 | ||||
| 8. Round | 10/09/2022 | KV Oostende | - | KAS Eupen | 1:0 |  |
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| 11. Round | 08/10/2022 | RFC Seraing | - | KV Oostende | 1:1 | ||||
| 13. Round | 20/10/2022 | Royal Antwerp FC | - | KV Oostende | 3:0 | ||||
| 14. Round | 23/10/2022 | KV Oostende | - | SV Zulte Waregem | 2:1 | ||||
| 15. Round | 29/10/2022 | Club Brugge KV | - | KV Oostende | 4:2 |  |
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| 16. Round | 06/11/2022 | KV Oostende | - | KV Kortrijk | 3:1 |
Belgium
Italy