| 1. Round | 07/08/2021 | Bolton Wanderers | - | Milton Keynes Dons | 3:3 |  |
|||
| 2. Round | 14/08/2021 | AFC Wimbledon | - | Bolton Wanderers | 3:3 | ||||
| 4. Round | 21/08/2021 | Bolton Wanderers | - | Oxford United | 2:1 | ||||
| 5. Round | 28/08/2021 | Cambridge United | - | Bolton Wanderers | 1:0 | ||||
| 7. Round | 11/09/2021 | Ipswich Town | - | Bolton Wanderers | 2:5 | ||||
| 10. Round | 28/09/2021 | Charlton Athletic | - | Bolton Wanderers | 1:4 | ||||
| 14. Round | 19/10/2021 | Plymouth Argyle | - | Bolton Wanderers | 3:0 | ||||
| 18. Round | 20/11/2021 | Wycombe Wanderers | - | Bolton Wanderers | 1:0 | ||||
| 20. Round | 27/11/2021 | Bolton Wanderers | - | Cheltenham Town | 2:2 | ||||
| 21. Round | 07/12/2021 | Fleetwood Town | - | Bolton Wanderers | 3:0 | ||||
| 22. Round | 11/12/2021 | Accrington Stanley | - | Bolton Wanderers | 1:0 | ||||
| 46. Round | 30/04/2022 | Bolton Wanderers | - | Fleetwood Town | 4:2 |
England
