| 2. Round | 26/09/2021 | AC Libertas | - | SC Faetano | 4:2 | ||||
| 4. Round | 16/10/2021 | SS Cosmos | - | SC Faetano | 0:3 | ||||
| 6. Round | 24/10/2021 | SS Folgore/Falciano | - | SC Faetano | 0:0 | ||||
| 18. Round | 29/01/2022 | SS Virtus | - | SC Faetano | 0:0 | ||||
| 22. Round | 20/02/2022 | FC Domagnano | - | SC Faetano | 1:3 | ||||
| 14. Round | 23/02/2022 | SC Faetano | - | SP Tre Penne | 0:0 |  |
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| 24. Round | 05/03/2022 | AC Juvenes/Dogana | - | SC Faetano | 1:2 | |
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| 26. Round | 13/03/2022 | SC Faetano | - | SP Tre Fiori | 0:1 | ||||
| 15. Round | 16/03/2022 | SP Cailungo | - | SC Faetano | 0:4 | ||||
| 17. Round | 05/04/2022 | SC Faetano | - | AC Libertas | 1:2 | ||||
| 28. Round | 09/04/2022 | SC Faetano | - | SS Murata | 3:2 | |
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| 30. Round | 21/04/2022 | SC Faetano | - | SP Cailungo | 4:1 |
San Marino