| 2. Round | 14/08/2021 | Oxford United | - | Charlton Athletic | 2:1 |  |
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| 3. Round | 17/08/2021 | Oxford United | - | Crewe Alexandra | 1:0 | |
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| 4. Round | 21/08/2021 | Bolton Wanderers | - | Oxford United | 2:1 | ||||
| 5. Round | 28/08/2021 | Oxford United | - | Lincoln City | 3:1 | ||||
| 6. Round | 04/09/2021 | AFC Wimbledon | - | Oxford United | 3:1 | ||||
| 7. Round | 11/09/2021 | Oxford United | - | Wycombe Wanderers | 0:0 | |
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| 8. Round | 18/09/2021 | Cheltenham Town | - | Oxford United | 1:0 | ||||
| 9. Round | 25/09/2021 | Oxford United | - | Gillingham FC | 1:1 | ||||
| 10. Round | 28/09/2021 | Oxford United | - | Accrington Stanley | 5:1 | ||||
| 11. Round | 02/10/2021 | Sheffield Wednesday | - | Oxford United | 1:2 | |
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| 14. Round | 19/10/2021 | Oxford United | - | Shrewsbury Town | 2:0 | ||||
| 15. Round | 23/10/2021 | Burton Albion | - | Oxford United | 1:3 | ||||
| 16. Round | 30/10/2021 | Oxford United | - | Morecambe FC | 3:1 |
Spain