| 1. Round | 14/01/2021 | LD Alajuelense | - | Municipal Pérez Zeledón | 2:0 | ||||
| 4. Round | 24/01/2021 | LD Alajuelense | - | AD San Carlos | 1:1 |  |
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| 3. Round | 28/01/2021 | Santos de Guápiles | - | LD Alajuelense | 0:3 | ||||
| 5. Round | 31/01/2021 | CS Herediano | - | LD Alajuelense | 1:1 |  |
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| 7. Round | 07/02/2021 | LD Alajuelense | - | Deportivo Saprissa | 3:1 | ||||
| 6. Round | 11/02/2021 | LD Alajuelense | - | Municipal Grecia | 3:0 | ||||
| 9. Round | 21/02/2021 | CS Cartaginés | - | LD Alajuelense | 1:1 | ||||
| 10. Round | 28/02/2021 | LD Alajuelense | - | Sporting FC | 3:0 | ||||
| 13. Round | 14/03/2021 | LD Alajuelense | - | Limón FC | 0:0 | ||||
| 14. Round | 21/03/2021 | LD Alajuelense | - | Santos de Guápiles | 1:1 | ||||
| 16. Round | 03/04/2021 | LD Alajuelense | - | CS Herediano | 1:1 | |
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| 18. Round | 18/04/2021 | Deportivo Saprissa | - | LD Alajuelense | 0:5 | |
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| 19. Round | 22/04/2021 | LD Alajuelense | - | Jicaral | 3:0 | ||||
| 20. Round | 25/04/2021 | LD Alajuelense | - | CS Cartaginés | 4:1 | |
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| 21. Round | 10/05/2021 | Sporting FC | - | LD Alajuelense | 1:2 | ||||
| 22. Round | 13/05/2021 | LD Alajuelense | - | Guadalupe | 0:0 |
Honduras