| 16. Round | 17/07/2021 | FK Smorgon | - | Energetik-BGU Minsk | 2:2 | ||||
| 18. Round | 30/07/2021 | Energetik-BGU Minsk | - | Rukh Brest | 0:2 | ||||
| 20. Round | 22/08/2021 | Energetik-BGU Minsk | - | BATE Borisov | 1:1 |  |
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| 21. Round | 29/08/2021 | Neman Grodno | - | Energetik-BGU Minsk | 3:0 | ||||
| 22. Round | 12/09/2021 | Energetik-BGU Minsk | - | Dinamo Minsk | 0:1 | ||||
| 23. Round | 17/09/2021 | Torpedo-BelAZ Zhodino | - | Energetik-BGU Minsk | 0:1 | |
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| 17. Round | 22/09/2021 | Shakhter Soligorsk | - | Energetik-BGU Minsk | 2:0 | ||||
| 24. Round | 26/09/2021 | Energetik-BGU Minsk | - | FK Vitebsk | 2:2 | ||||
| 26. Round | 17/10/2021 | Energetik-BGU Minsk | - | Dinamo Brest | 0:0 | ||||
| 27. Round | 23/10/2021 | FK Gomel | - | Energetik-BGU Minsk | 4:0 | |
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| 28. Round | 06/11/2021 | Energetik-BGU Minsk | - | FK Minsk | 1:1 |  |
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| 29. Round | 20/11/2021 | Energetik-BGU Minsk | - | FK Slaviya Mozyr | 2:3 |
Belarus