| 10. Round | 10/10/2021 | Herrera FC | - | Plaza Amador | 0:2 | ||||
| 11. Round | 17/10/2021 | Herrera FC | - | Alianza | 1:1 | ||||
| 12. Round | 24/10/2021 | Herrera FC | - | Independiente de La Chorrera | 2:1 | ||||
| 13. Round | 31/10/2021 | Atlético Chiriquí | - | Herrera FC | 0:0 | ||||
| 14. Round | 06/11/2021 | Herrera FC | - | Veraguas Club Deportivo | 1:1 | ||||
| 15. Round | 13/11/2021 | Herrera FC | - | San Francisco FC | 2:1 |  |
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| 16. Round | 20/11/2021 | UD Universitario | - | Herrera FC | 1:2 |
Panama