| 1. Round | 24/01/2021 | Juventus Managua | - | ART Municipal Jalapa | 3:1 | ||||
| 2. Round | 28/01/2021 | CD Walter Ferretti | - | Juventus Managua | 1:0 |  |
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| 3. Round | 31/01/2021 | Juventus Managua | - | Diriangén FC | 1:0 | ||||
| 4. Round | 05/02/2021 | Juventus Managua | - | Real Estelí FC | 0:1 | ||||
| 5. Round | 07/02/2021 | Juventus Managua | - | Managua FC | 0:5 | |
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| 6. Round | 11/02/2021 | Club Deportivo Ocotal | - | Juventus Managua | 1:0 | |
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| 7. Round | 14/02/2021 | Juventus Managua | - | Chinandega | 1:3 |  |
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| 10. Round | 08/03/2021 | ART Municipal Jalapa | - | Juventus Managua | 1:0 | ||||
| 14. Round | 19/04/2021 | Managua FC | - | Juventus Managua | 4:1 | ||||
| 15. Round | 25/04/2021 | Juventus Managua | - | Club Deportivo Ocotal | 3:1 | ||||
| 16. Round | 29/04/2021 | Chinandega | - | Juventus Managua | 0:0 |
Nicaragua