| 1. Round | 24/08/2020 | FC Voluntari | - | Gaz Metan Mediaş | 2:1 | ||||
| 2. Round | 28/08/2020 | Gaz Metan Mediaş | - | Argeș Pitești | 2:0 | ||||
| 3. Round | 12/09/2020 | FC Politehnica Iași | - | Gaz Metan Mediaş | 1:4 | ||||
| 4. Round | 21/09/2020 | Gaz Metan Mediaş | - | Dinamo Bucureşti | 1:3 | ||||
| 5. Round | 26/09/2020 | Academica Clinceni | - | Gaz Metan Mediaş | 2:0 | ||||
| 6. Round | 04/10/2020 | Gaz Metan Mediaş | - | FC Hermannstadt | 1:1 | ||||
| 7. Round | 17/10/2020 | Chindia Târgoviște | - | Gaz Metan Mediaş | 1:0 | ||||
| 8. Round | 23/10/2020 | Gaz Metan Mediaş | - | FC Botoşani | 1:2 | ||||
| 9. Round | 01/11/2020 | CFR Cluj | - | Gaz Metan Mediaş | 1:2 |  |
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| 10. Round | 09/11/2020 | UTA Arad | - | Gaz Metan Mediaş | 1:3 | ||||
| 11. Round | 23/11/2020 | Gaz Metan Mediaş | - | FCSB | 2:3 | ||||
| 12. Round | 07/12/2020 | CS Universitatea Craiova | - | Gaz Metan Mediaş | 3:1 | ||||
| 13. Round | 12/12/2020 | Gaz Metan Mediaş | - | Sepsi OSK | 0:3 | ||||
| 14. Round | 15/12/2020 | Astra Giurgiu | - | Gaz Metan Mediaş | 3:0 | ||||
| 24. Round | 21/02/2021 | Gaz Metan Mediaş | - | CFR Cluj | 0:1 | ||||
| 25. Round | 27/02/2021 | Gaz Metan Mediaş | - | UTA Arad | 1:2 |
Romania