| 1. Round | 28/07/2017 | Royal Antwerp FC | - | RSC Anderlecht | 0:0 | ||||
| 2. Round | 06/08/2017 | RSC Anderlecht | - | KV Oostende | 1:0 | ||||
| 3. Round | 13/08/2017 | Sporting Charleroi | - | RSC Anderlecht | 2:0 |  |
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| 4. Round | 20/08/2017 | RSC Anderlecht | - | Sint-Truidense VV | 2:3 | ||||
| 5. Round | 27/08/2017 | KAA Gent | - | RSC Anderlecht | 0:0 | ||||
| 6. Round | 08/09/2017 | RSC Anderlecht | - | Sporting Lokeren | 3:2 | ||||
| 7. Round | 16/09/2017 | KV Kortrijk | - | RSC Anderlecht | 2:2 | ||||
| 9. Round | 01/10/2017 | RSC Anderlecht | - | Standard Liège | 1:0 | ||||
| 10. Round | 13/10/2017 | KV Mechelen | - | RSC Anderlecht | 3:4 | ||||
| 12. Round | 25/10/2017 | RSC Anderlecht | - | SV Zulte Waregem | 2:0 | ||||
| 13. Round | 28/10/2017 | KAS Eupen | - | RSC Anderlecht | 2:3 | ||||
| 14. Round | 05/11/2017 | RSC Anderlecht | - | Club Brugge KV | 0:0 | ||||
| 25. Round | 04/02/2018 | RSC Anderlecht | - | KV Mechelen | 2:2 | ||||
| 26. Round | 10/02/2018 | KV Oostende | - | RSC Anderlecht | 2:0 | |
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| 27. Round | 16/02/2018 | Sint-Truidense VV | - | RSC Anderlecht | 1:0 | ||||
| 28. Round | 25/02/2018 | RSC Anderlecht | - | Royal Excel Mouscron | 5:3 |
Romania