| 1. Round | 26/02/2022 | Columbus Crew | - | Vancouver Whitecaps | 4:0 | ||||
| 2. Round | 20/03/2022 | New York RB | - | Columbus Crew | 1:1 | ||||
| 3. Round | 02/04/2022 | Columbus Crew | - | Nashville SC | 0:1 | ||||
| 3. Round | 09/04/2022 | Philadelphia Union | - | Columbus Crew | 1:0 | ||||
| 3. Round | 17/04/2022 | Columbus Crew | - | Orlando City | 0:2 | ||||
| 5. Round | 26/06/2022 | Real Salt Lake | - | Columbus Crew | 0:0 |
Romania