| 1. Round | 12/09/2021 | PAOK Saloniki | - | PAS Giannina | 0:1 | ||||
| 2. Round | 19/09/2021 | Asteras Tripolis | - | PAOK Saloniki | 0:1 | ||||
| 3. Round | 22/09/2021 | Panetolikos | - | PAOK Saloniki | 1:2 |  |
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| 4. Round | 26/09/2021 | PAOK Saloniki | - | AEK Athen | 2:0 | ||||
| 5. Round | 03/10/2021 | OFI Heraklion | - | PAOK Saloniki | 1:3 | ||||
| 6. Round | 17/10/2021 | PAOK Saloniki | - | Volos NFC | 4:4 | ||||
| 7. Round | 24/10/2021 | Olympiakos Piraeus | - | PAOK Saloniki | 2:1 | ||||
| 11. Round | 28/11/2021 | PAOK Saloniki | - | Aris Saloniki | 0:1 | ||||
| 16. Round | 12/01/2022 | PAOK Saloniki | - | Panetolikos | 2:0 | ||||
| 18. Round | 15/01/2022 | PAOK Saloniki | - | OFI Heraklion | 3:0 | ||||
| 19. Round | 23/01/2022 | Volos NFC | - | PAOK Saloniki | 0:4 | ||||
| 20. Round | 30/01/2022 | PAOK Saloniki | - | Olympiakos Piraeus | 1:1 | ||||
| 22. Round | 06/02/2022 | PAOK Saloniki | - | Panathinaikos | 2:1 | |
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| 23. Round | 13/02/2022 | PAOK Saloniki | - | Atromitos | 1:0 | ||||
| 25. Round | 27/02/2022 | PAOK Saloniki | - | Ionikos Nikea | 1:1 | |
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