| 24. Round | 05/02/2022 | UTA Arad | - | Sepsi OSK | 1:0 | ||||
| 25. Round | 08/02/2022 | Sepsi OSK | - | Gaz Metan Mediaş | 2:0 |  |
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| 26. Round | 11/02/2022 | Rapid Bucureşti | - | Sepsi OSK | 1:1 | ||||
| 27. Round | 19/02/2022 | FC Voluntari | - | Sepsi OSK | 3:1 | ||||
| 28. Round | 26/02/2022 | Sepsi OSK | - | CFR Cluj | 0:2 | ||||
| 29. Round | 01/03/2022 | Dinamo Bucureşti | - | Sepsi OSK | 1:3 | ||||
| 30. Round | 04/03/2022 | Sepsi OSK | - | FC Universitatea Craiova | 2:1 | |
Romania