| 2. Round | 30/07/2021 | Arsenal Tula | - | Rubin Kazan | 0:3 | ||||
| 3. Round | 07/08/2021 | Arsenal Tula | - | Krylia Sovetov | 2:1 | ||||
| 5. Round | 21/08/2021 | Arsenal Tula | - | Spartak Moskva | 1:1 | ||||
| 6. Round | 26/08/2021 | Akhmat Grozny | - | Arsenal Tula | 2:1 | ||||
| 10. Round | 02/10/2021 | Arsenal Tula | - | FK Khimki | 0:0 | ||||
| 12. Round | 23/10/2021 | FK Rostov | - | Arsenal Tula | 4:0 |
Romania