| 2. Round | 06/03/2022 | Deportivo La Guaira | - | Academia Puerto Cabello | 2:1 | ||||
| 3. Round | 10/03/2022 | Academia Puerto Cabello | - | Aragua FC | 2:1 | ||||
| 4. Round | 18/03/2022 | Deportivo Táchira | - | Academia Puerto Cabello | 1:1 | ||||
| 5. Round | 25/03/2022 | Hermanos Colmenarez | - | Academia Puerto Cabello | 4:1 | ||||
| 9. Round | 24/04/2022 | Deportivo Lara | - | Academia Puerto Cabello | 1:2 | ||||
| 10. Round | 30/04/2022 | Academia Puerto Cabello | - | Estudiantes de Mérida | 1:0 | ||||
| 11. Round | 08/05/2022 | Universidad Central | - | Academia Puerto Cabello | 2:2 | ||||
| 12. Round | 15/05/2022 | Academia Puerto Cabello | - | Carabobo FC | 1:1 | ||||
| 13. Round | 20/05/2022 | Zamora FC | - | Academia Puerto Cabello | 1:0 |
Panama