| 3. Round | 10/02/2022 | CD Walter Ferretti | - | Diriangén FC | 2:3 | ||||
| 4. Round | 14/02/2022 | ART Municipal Jalapa | - | CD Walter Ferretti | 3:2 | ||||
| 5. Round | 20/02/2022 | UNAN Managua | - | CD Walter Ferretti | 2:2 |  |
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| 6. Round | 27/02/2022 | CD Walter Ferretti | - | H&H Export Sébaco | 5:0 | ||||
| 8. Round | 07/03/2022 | CD Walter Ferretti | - | Real Estelí FC | 2:3 | ||||
| 9. Round | 11/03/2022 | Managua FC | - | CD Walter Ferretti | 2:1 | ||||
| 16. Round | 24/04/2022 | H&H Export Sébaco | - | CD Walter Ferretti | 2:0 | ||||
| 17. Round | 28/04/2022 | Real Estelí FC | - | CD Walter Ferretti | 0:0 | ||||
| 18. Round | 02/05/2022 | CD Walter Ferretti | - | Managua FC | 1:0 |
Nicaragua