| 1. Round | 10/07/2022 | Macará | - | Emelec | 1:3 | ||||
| 2. Round | 18/07/2022 | Emelec | - | Independiente del Valle | 2:3 | ||||
| 3. Round | 24/07/2022 | Guayaquil City | - | Emelec | 0:0 | ||||
| 4. Round | 01/08/2022 | Emelec | - | Gualaceo SC | 2:1 | ||||
| 6. Round | 15/08/2022 | LDU Quito | - | Emelec | 2:0 |  |
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| 8. Round | 28/08/2022 | 9 de Octubre | - | Emelec | 0:3 |  |
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| 9. Round | 03/09/2022 | Emelec | - | Cumbayá | 1:0 | ||||
| 12. Round | 02/10/2022 | Mushuc Runa | - | Emelec | 0:0 | ||||
| 13. Round | 10/10/2022 | Emelec | - | Orense SC | 0:0 |
Colombia