| 1. Round | 04/09/2021 | PSIS Semarang | - | Persela Lamongan | 1:0 | ||||
| 2. Round | 12/09/2021 | Persija Jakarta | - | PSIS Semarang | 2:2 | ||||
| 3. Round | 18/09/2021 | PSIS Semarang | - | Persiraja Banda Aceh | 3:1 | ||||
| 4. Round | 25/09/2021 | Arema Cronus FC | - | PSIS Semarang | 0:0 |  |
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| 6. Round | 03/10/2021 | Persebaya Surabaya | - | PSIS Semarang | 2:3 | |
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| 19. Round | 12/01/2022 | Persiraja Banda Aceh | - | PSIS Semarang | 0:1 | ||||
| 20. Round | 17/01/2022 | PSIS Semarang | - | Arema Cronus FC | 0:0 | ||||
| 23. Round | 06/02/2022 | Persik Kediri | - | PSIS Semarang | 0:0 | ||||
| 25. Round | 15/02/2022 | Persib Bandung | - | PSIS Semarang | 0:0 | ||||
| 26. Round | 20/02/2022 | PSIS Semarang | - | Bali United | 0:1 | |
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| 28. Round | 28/02/2022 | PSIS Semarang | - | Persikabo 1973 | 1:0 | ||||
| 29. Round | 06/03/2022 | PSM Makassar | - | PSIS Semarang | 2:1 | ||||
| 30. Round | 12/03/2022 | PSIS Semarang | - | Bhayangkara Presisi Indonesia | 1:1 |  |
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| 31. Round | 16/03/2022 | PSS Sleman | - | PSIS Semarang | 0:1 | ||||
| 32. Round | 20/03/2022 | PSIS Semarang | - | Persita Tangerang | 3:3 | ||||
| 33. Round | 24/03/2022 | PSIS Semarang | - | Persipura Jayapura | 0:4 | ||||
| 34. Round | 29/03/2022 | Persela Lamongan | - | PSIS Semarang | 1:2 | |
Indonesia