| 1. Round | 16/01/2021 | Orsomarso SC | - | Barranquilla FC | 2:2 | ||||
| 2. Round | 22/01/2021 | Barranquilla FC | - | Boca Juniors de Cali | 0:1 | ||||
| 3. Round | 01/02/2021 | Real Cartagena | - | Barranquilla FC | 1:0 | ||||
| 4. Round | 06/02/2021 | Barranquilla FC | - | Real Santander | 1:0 | ||||
| 5. Round | 11/02/2021 | Bogotá FC | - | Barranquilla FC | 1:0 |  |
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| 6. Round | 15/02/2021 | Barranquilla FC | - | Fortaleza FC | 1:2 | ||||
| 7. Round | 22/02/2021 | Leones FC | - | Barranquilla FC | 2:1 | ||||
| 8. Round | 27/02/2021 | Barranquilla FC | - | Atlético Huila | 0:0 | ||||
| 9. Round | 04/03/2021 | Cortuluá | - | Barranquilla FC | 1:1 | ||||
| 10. Round | 07/03/2021 | Barranquilla FC | - | Atlético FC | 0:1 | ||||
| 12. Round | 21/03/2021 | Valledupar FC | - | Barranquilla FC | 2:0 | ||||
| 15. Round | 09/04/2021 | Barranquilla FC | - | Deportes Quindío | 0:0 |
Colombia