| 3. Round | 01/08/2021 | Cusco FC | - | Alianza Universidad | 2:3 | ||||
| 4. Round | 04/08/2021 | FBC Melgar | - | Cusco FC | 2:2 | ||||
| 5. Round | 08/08/2021 | Cusco FC | - | Alianza Atlético | 3:0 | ||||
| 6. Round | 13/08/2021 | Universidad Técnica | - | Cusco FC | 2:1 | ||||
| 7. Round | 17/08/2021 | Cusco FC | - | Mannucci | 2:3 | ||||
| 8. Round | 23/08/2021 | Sporting Cristal | - | Cusco FC | 4:1 | ||||
| 10. Round | 11/09/2021 | Ayacucho FC | - | Cusco FC | 1:3 |  |
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| 16. Round | 23/10/2021 | Universitario de Deportes | - | Cusco FC | 2:1 | ||||
| 17. Round | 30/10/2021 | Cusco FC | - | Sport Huancayo | 2:1 |
Peru