| 7. Round | 09/01/2021 | RC Rélizane | - | US Biskra | 2:0 | ||||
| 8. Round | 15/01/2021 | US Biskra | - | USM Bel Abbes | 0:1 | ||||
| 9. Round | 22/01/2021 | Olympique Médéa | - | US Biskra | 1:0 | ||||
| 10. Round | 26/01/2021 | US Biskra | - | CAB Bou Arreridj | 1:1 | ||||
| 11. Round | 30/01/2021 | MC Alger | - | US Biskra | 1:1 |  |
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| 12. Round | 06/02/2021 | US Biskra | - | CS Constantine | 0:1 | ||||
| 13. Round | 12/02/2021 | MC Oran | - | US Biskra | 6:0 | ||||
| 18. Round | 17/03/2021 | ASO Chlef | - | US Biskra | 1:0 | ||||
| 19. Round | 21/03/2021 | US Biskra | - | CR Bélouizdad | 1:0 | |
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| 25. Round | 13/06/2021 | JS Kabylie | - | US Biskra | 1:1 | |
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| 26. Round | 19/06/2021 | US Biskra | - | RC Rélizane | 3:2 | ||||
| 27. Round | 26/06/2021 | USM Bel Abbes | - | US Biskra | 1:0 | ||||
| 28. Round | 01/07/2021 | US Biskra | - | Olympique Médéa | 2:2 | ||||
| 31. Round | 13/07/2021 | CS Constantine | - | US Biskra | 1:1 | ||||
| 32. Round | 17/07/2021 | US Biskra | - | MC Oran | 1:0 | ||||
| 33. Round | 23/07/2021 | USM Alger | - | US Biskra | 2:1 | ||||
| 34. Round | 27/07/2021 | US Biskra | - | JS Saoura | 1:2 |
Algeria