| 1. Round | 23/10/2021 | RC Arbaâ | - | US Biskra | 0:5 | ||||
| 2. Round | 29/10/2021 | US Biskra | - | JS Saoura | 2:1 |  |
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| 3. Round | 07/11/2021 | US Biskra | - | RC Rélizane | 1:0 | ||||
| 8. Round | 17/12/2021 | MC Oran | - | US Biskra | 2:2 | ||||
| 9. Round | 24/12/2021 | US Biskra | - | CR Bélouizdad | 0:1 | ||||
| 10. Round | 29/12/2021 | NC Magra | - | US Biskra | 1:0 | ||||
| 16. Round | 29/01/2022 | ES Sétif | - | US Biskra | 2:0 | ||||
| 21. Round | 11/03/2022 | US Biskra | - | USM Alger | 0:0 | ||||
| 22. Round | 18/03/2022 | HB Chelghoum Laïd | - | US Biskra | 3:1 | ||||
| 27. Round | 22/04/2022 | US Biskra | - | NC Magra | 1:0 | ||||
| 28. Round | 29/04/2022 | WA Tlemcen | - | US Biskra | 0:3 | ||||
| 29. Round | 07/05/2022 | US Biskra | - | MC Alger | 0:0 | ||||
| 30. Round | 14/05/2022 | CS Constantine | - | US Biskra | 0:0 | |
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| 31. Round | 20/05/2022 | US Biskra | - | Paradou AC | 1:0 | ||||
| 32. Round | 27/05/2022 | Olympique Médéa | - | US Biskra | 1:1 | ||||
| 33. Round | 05/06/2022 | US Biskra | - | ES Sétif | 1:1 |
Algeria