3. Round | 16/08/2021 | Managua FC | - | Real Estelí FC | 3:0 | ||||
4. Round | 22/08/2021 | H&H Export Sébaco | - | Managua FC | 0:0 | ||||
5. Round | 30/08/2021 | Managua FC | - | Diriangén FC | 1:2 | ||||
7. Round | 13/09/2021 | UNAN Managua | - | Managua FC | 2:3 | ||||
6. Round | 23/09/2021 | Managua FC | - | Club Deportivo Ocotal | 3:1 | ||||
9. Round | 27/09/2021 | CD Walter Ferretti | - | Managua FC | 0:0 | ||||
14. Round | 25/10/2021 | Diriangén FC | - | Managua FC | 0:3 | ||||
15. Round | 31/10/2021 | Managua FC | - | UNAN Managua | 3:0 | ||||
16. Round | 05/11/2021 | Club Deportivo Ocotal | - | Managua FC | 1:0 | ||||
17. Round | 18/11/2021 | Real Madriz | - | Managua FC | 1:3 |