| 1. Round | 05/08/2010 | Haras El Hodood | - | Zamalek | 2:2 |  |
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| 2. Round | 15/08/2010 | Zamalek | - | PetroJet FC | 2:0 | |
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| 3. Round | 23/08/2010 | ENPPI | - | Zamalek | 3:1 | ||||
| 5. Round | 13/09/2010 | Zamalek | - | El Gouna | 1:1 | |
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| 6. Round | 17/09/2010 | Smouha Sporting Club | - | Zamalek | 1:3 | ||||
| 7. Round | 27/09/2010 | Zamalek | - | Al Mokawloon | 1:0 | ||||
| 8. Round | 02/10/2010 | Misr lel-Maqasah SC | - | Zamalek | 3:4 |  |
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| 20. Round | 10/05/2011 | El Gouna | - | Zamalek | 2:1 | ||||
| 21. Round | 15/05/2011 | Zamalek | - | Smouha Sporting Club | 3:0 | ||||
| 22. Round | 21/05/2011 | Al Mokawloon | - | Zamalek | 2:3 | ||||
| 23. Round | 26/05/2011 | Zamalek | - | Misr lel-Maqasah SC | 0:1 |
Egypt