| 23. Round | 19/02/2022 | AZ Alkmaar | - | Heracles Almelo | 2:1 | ||||
| 24. Round | 26/02/2022 | Heracles Almelo | - | PEC Zwolle | 2:0 | ||||
| 25. Round | 06/03/2022 | PSV Eindhoven | - | Heracles Almelo | 3:1 |  |
|||
| 26. Round | 13/03/2022 | Heracles Almelo | - | Vitesse | 0:0 | ||||
| 27. Round | 18/03/2022 | sc Heerenveen | - | Heracles Almelo | 2:0 | ||||
| 28. Round | 03/04/2022 | Fortuna Sittard | - | Heracles Almelo | 0:2 | ||||
| 29. Round | 10/04/2022 | Heracles Almelo | - | Feyenoord | 1:4 | |
|||
| 30. Round | 24/04/2022 | FC Groningen | - | Heracles Almelo | 0:1 | ||||
| 31. Round | 30/04/2022 | Heracles Almelo | - | FC Twente | 1:1 |  |
|||
| 34. Round | 15/05/2022 | Heracles Almelo | - | Sparta Rotterdam | 1:3 |
Germany