| 1. Round | 16/04/2021 | Monagas | - | Mineros de Guayana | 2:0 | ||||
| 11. Round | 27/06/2021 | Mineros de Guayana | - | Caracas FC | 2:2 | ||||
| 12. Round | 02/07/2021 | Mineros de Guayana | - | Metropolitanos FC | 1:0 |  |
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| 13. Round | 08/07/2021 | LALA FC | - | Mineros de Guayana | 1:2 | ||||
| 14. Round | 15/07/2021 | Universidad Central | - | Mineros de Guayana | 1:0 | |
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| 16. Round | 30/07/2021 | Mineros de Guayana | - | Atlético Venezuela | 1:2 | ||||
| 18. Round | 14/08/2021 | Caracas FC | - | Mineros de Guayana | 2:0 | ||||
| 19. Round | 19/08/2021 | Metropolitanos FC | - | Mineros de Guayana | 3:0 | ||||
| 20. Round | 26/08/2021 | Mineros de Guayana | - | LALA FC | 2:0 | ||||
| 25. Round | 30/09/2021 | Mineros de Guayana | - | Caracas FC | 1:1 |  |
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| 26. Round | 06/10/2021 | Mineros de Guayana | - | Metropolitanos FC | 0:0 |
Venezuela