| 5. Round | 07/02/2021 | CD Walter Ferretti | - | Diriangén FC | 2:0 | ||||
| 6. Round | 11/02/2021 | CD Walter Ferretti | - | Real Estelí FC | 0:1 | ||||
| 7. Round | 14/02/2021 | CD Walter Ferretti | - | Managua FC | 2:1 | ||||
| 8. Round | 18/02/2021 | Club Deportivo Ocotal | - | CD Walter Ferretti | 3:0 | ||||
| 14. Round | 18/04/2021 | Diriangén FC | - | CD Walter Ferretti | 1:1 | ||||
| 15. Round | 26/04/2021 | Real Estelí FC | - | CD Walter Ferretti | 2:1 | ||||
| 16. Round | 29/04/2021 | Managua FC | - | CD Walter Ferretti | 3:1 |
Nicaragua