| 1. Round | 12/07/2015 | CS Universitatea Craiova | - | FC Botoşani | 0:0 | ||||
| 3. Round | 27/07/2015 | ACS Poli Timişoara | - | FC Botoşani | 1:0 |  |
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| 5. Round | 07/08/2015 | FC Voluntari | - | FC Botoşani | 1:1 | ||||
| 7. Round | 14/08/2015 | Petrolul Ploieşti | - | FC Botoşani | 2:1 | ||||
| 8. Round | 22/08/2015 | FC Botoşani | - | Pandurii Târgu Jiu | 0:2 | ||||
| 9. Round | 31/08/2015 | CFR Cluj | - | FC Botoşani | 3:1 | ||||
| 12. Round | 27/09/2015 | Astra Giurgiu | - | FC Botoşani | 1:0 | ||||
| 13. Round | 04/10/2015 | FC Botoşani | - | ASA Târgu Mureş | 1:1 | |
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| 17. Round | 08/11/2015 | FC Steaua Bucureşti | - | FC Botoşani | 5:3 |  |
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| 20. Round | 02/12/2015 | FC Botoşani | - | Petrolul Ploieşti | 2:1 | ||||
| 21. Round | 05/12/2015 | Pandurii Târgu Jiu | - | FC Botoşani | 0:3 | ||||
| 22. Round | 13/12/2015 | FC Botoşani | - | CFR Cluj | 2:1 | ||||
| 23. Round | 18/12/2015 | FC Botoşani | - | Concordia Chiajna | 5:1 | ||||
| 24. Round | 14/02/2016 | Dinamo Bucureşti | - | FC Botoşani | 1:0 | ||||
| 25. Round | 19/02/2016 | FC Botoşani | - | Astra Giurgiu | 0:1 | |
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| 26. Round | 27/02/2016 | ASA Târgu Mureş | - | FC Botoşani | 1:0 |
Romania